Fig. 3. Effect of linoleic acid (LA) on citrate synthase (CS) activity and cellular respiration of Swan71 cells. A) 300 and 500 μM of LA significantly decreased CS activity (n=5).B) 300 and 500 μM of LA significantly decreased routine respiration (n=3). C-D) 100, 300 and 500 μM of LA significantly decreased maximal respiration (electron transport system (ETS) respiration) and spare respiratory capacity (n=3). E) 300 and 500 μM of LA significantly increased H2O2 production (n=5). Data expressed as mean ±SEM. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001 compared to vehicle control (BSA+ EtOH).